Synergy ID: 1435268
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Arginine

l-arginine

L-arginine - the most important component ProArgi-9 Plus - is essential for the production of nitric oxide (NO) in the body. Nitric oxide is an important factor in the regulation of blood pressure.

L-arginine is also involved in many other important biochemical processes. None of this amino acid can seriously disrupt. Another important element of this process is the l-citrulline, which raises the level of l-arginine in the blood and prolongs its effect.

L-arginine occurs naturally in the human body. It is an amino acid endogenous therefore one that can be produced by the body from other compounds.

Theoretically, the body does not need a supply of this amino acid from the food. Unfortunately, as research has shown, with age the ability to synthesize arginine in the human body begins to decrease.

Arginine deficiency and lead to an imbalance inside the body. Proper supplementation restores the appropriate level of the amino acid, which is important because of its vital functions.

In human research, L-arginine administration has been effective at: Preventing reduced aortic reflection times, reducing LDL-C oxidizability, improves blood supply to the heart muscle in people with angina, reducing overall heart rate, increases the painless distance in people with intermittent claudication, reducing platelet aggregation, decreasing systemic vascular resistance, preventing thickening of aortic intimal, increasing monocytic adhesion and improving stroke volume.

PA9+ contains natural l-arginine in free form (not HCL), produced in the process of carbohydrate fermentation.

L-Arginine - Scientific Validation

  1. KochupurackalP,etal.Nitricoxide:anantioxidantandneuroprotector.Annals of the New York Academy of Sciences. 2002; 962:389-401.
  2. Kumar CA, Das UN. Lipid peroxides, antioxidants and nitric oxide in pa- tients with pre-eclampsia and essential hypertension. Med Sci Monitor. 2000 Sep-Oct; 6(5):901-7.
  3. 18. Brown, M.D., Dengel, D.R., Supiano, M.A. Nitric Oxide Biomarkers are As- sociated with the Blood Pressure-Lowering Effects of Dietary Sodium Restriction in Older Hypertensives. Circulation (Abstract I). 1997; 96:I-539.
  4. Rosano, G.M.C., Tanina, G., Cerquetani, E., Leonardo, F., Pelliccia, F., Bonfigli, B., and Chierchia, F.L. L-arginine Improves Endothelial Function in Newly Diagnosed Hypertensives. The Journal of the American College of Cardiology (Supplement A). 1998; 31:262a
  5. Moncada, F., Palmer, R.M.J., Higgs, E.A. The Discovery of Nitric Oxide as the Endogenous Nitrovasodilator. Hypertension. 1988; 12:365-72.
  6. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory impairment. Med Hypotheses. 1994 Jun; 42(6):363-6.
  7. Tarkowski E, et al. Intrathecal release of nitric oxide in Alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord. 2000 Nov-Dec; 11(6):322-6.
  8. Ghigo E, Arvat E, Gianotti L, et al. Hypothalamic growth hormone-insulin-like growth facto-1 axis across the human life span. J Pediatr Endocrinol Metab.2000; 13 Suppl 6:1493-502.
  9. Fried R, Merrell WC. The Arginine Solution. New York, NY. Warner Books, 1999.
  10. Efron D, Barbul A. Role of arginine in immunonutrition. J Gastroentol. 2000; 35 Suppl 12:20-3..
  11. Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE. A randomized double-blind study of oral L-arginine for treatment of interstitial cystitis. J Urol. 1999 Feb; 161(2):558-65.
  12. Piatti PM, Monti LD, Valsecchi G, et al. Long term oral L-arginine admin- istration improves peripheral and hepatic insulin sensitivity in type 2 diabetes. Diabetes Care. 2001 May; 24(5):875-80.
  13. 28. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free Radic Biol Med. 1998 Nov 1; 25(7):757-65.
  14. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colorectal cancer. Br J Surg. 1997 Feb; 84(2):238-41.
  15. Brittenden J, et al. Dietary supplementation with L-arginine in patients with breast cancer (> 4cm.) receiving multi-modality treatment: report of a feasibility study. Br J Cancer. 1994 May; 69(5):918-21.
  16. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega) nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr. 1996 Oct; 126(10):2563-7.
  17. Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int. 1999 Feb; 83(3):269-73.
  18. 33. Wolf A, et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol. 1997 Mar 1; 29(3):479.
  19. Podjarny, E., et al. Pregnancy-induced hypertension in rats with adriamycin nephropathy is associated with inadequate production of nitric oxide. Hypertension. 1997; 29:986-991.
  20. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness to histamine in asthma. Thorax. 1999 Nov; 54(11):1033-5.
  21. De Gouw HW, Marshall-Partridge SJ, et al. Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects. J Appl Physiol. 2001 Feb; 90(2):586-92.
  22. Fried R, Merrell WC. The Arginine Solution. New York, New York. Warner Books, 1999. pp 4-5.
  23. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc. 2000 Dec; 32(12):2102-8.
  24. Heitzer, T., Just, H., and Munzell, T. Antioxidant Vitamin C Improves Endothelium Function in Chronic Smokers. Circulation. 1996; 94:9.
  25. Zeiher, A.M., Schachinger, V., and Minners, J. Long-Term Cigarette Smoking Impairs Endothelium-Dependent Coronary Arterial Vasodilator Function. Circulation. 1995; 92:1094-1100.
  26. Barbul A, et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990 Aug; 108(2):331-6; discussion 336-7.
  27. Braga M, Gianotti L Raedelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg. 1999 Apr; 134(4):428-33.
  28. De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J of Nutri. 1998 May; 128(5):797-803.
  29. Kirk SJ, et al Arginine stimulates wound healing and immune function in elderly humans. Surgery. 1993 Aug; 114(2):155-9; discussion 160.
  30. Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercised induced QT dispersion and exercise tolerance in stable anginapectoris. Int J Cardiol. 2000 Sep 15; 75(2-3): 205-10.
  31. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the change with aging. Prostate. 2001 Jun 15; 48(1):40-6.
  32. Fini M, et al. Effect of l-lysine and L-arginine on primary osteoblast cultures from normal and osteopenic rats. Biomed Pharmacother. 2001 May; 55(4):213-21.
  33. Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses. Methods Find Exp Clin Pharmacol. 2001 Jan-Feb; 23(1):13-7.
  34. Ohta Y, Nishida K., Protective effect of l-arginine against stress-induced gastric mucosal lesions in rats and its relation to nitric acid-mediated inhibition of neutrophil infiltration. Pharmacal Res. 2001 Jun; 43(6):535-41.
  35. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indo- methacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res. 2001 May; 43(5):463-7.
  36. De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of arginine supplementation in chronic renal failure. Kidney Int. 1999 Aug; 56(2):674-84.
  37. Reckelhoff JF, et al. Long-term dietary supplementation with L-arginine prevents age related reduction in renal function. Am J Physiol. 1997 Jun; 272(6 Pt 2):1768-74.
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